Objective To construct an individualized management scheme of fluid intake for patients with chronic heart failure（CHF） and discuss its application effect. Methods Based on the previous results of “maximum cumulative fluid balance and number of days for CHF patients with safe volume load” and overhydration（OH） value at the time of entry,an individualized management scheme of fluid intake for patients with CHF was developed. Using the convenience sampling method,278 patients with CHF admitted to a tertiary first-class hospital in Jiangsu Province from May to October 2020 were selected. By the random number table method,the patients were randomly divided into an experimental group （139 cases） and a control group （139 cases）. The experimental group adopts an individualized management scheme of fluid intake,and the control group adopts the department’s routine fluid management strategies and we evaluated the effect of the intervention. Results After the intervention,OH value,estimated plasma volume status,Clinical Congestion Scale,Thirst Distress Scale-Heart Failure,the Minnesota Living with Heart Failure Questionnaire,3-and 6-month post-discharge readmission rates in the experimental group were lower than those in the control group（P<0.05）. There was no significant difference between 2 groups in 3- and 6-month post-discharge cardiac mortality （P>0.05）. Conclusion The individualized management scheme of fluid intake for patients with CHF can improve volume status and quality of life,providing a basis for management of fluid intake for patients with CHF.